Ozempic (Semaglutide) 1.34mg/ml (0.25mg, 0.5mg/dose) Pre-filled Pen 1 Pen

Ozempic (Semaglutide) 1.34mg/ml (0.25mg, 0.5mg/dose) Pre-filled Pen is an injectable GLP-1 receptor agonist medication indicated for adults with type 2 diabetes to improve blood sugar control and reduce cardiovascular and chronic kidney disease (CKD) risks. It was officially HSA-approved in April 2021 specifically for the treatment of type 2 diabetes. While semaglutide is widely recognized for promoting weight management, any use of Ozempic solely for weight loss is considered off-label and remains strictly at the discretion of a qualified doctor.

This pre-filled pen contains the initial titration doses (0.25mg and 0.5mg), which are used to help patients gradually adapt to semaglutide treatment while minimizing gastrointestinal side effects. It works by stimulating insulin release when blood sugar levels are elevated, suppressing excessive glucose production by the liver, and slowing gastric emptying to increase feelings of fullness after meals.

Semaglutide is trusted by doctors around the world and is supported by extensive clinical studies demonstrating its effectiveness in managing type 2 diabetes and reducing cardiovascular risk. The convenient once-weekly dosing schedule makes it easier for many patients to stay consistent with treatment during the initiation and dose-escalation phases. Prescribed globally, including throughout Singapore, Ozempic has become one of the most widely recognized GLP-1 receptor agonists for comprehensive diabetes management.

Want the science first? Start with how Ozempic actually works in the body.

Ozempic is an authentic, prescription-only GLP-1 receptor agonist approved by Singapore's Health Sciences Authority (HSA) for adults with type 2 diabetes whose blood sugar levels remain inadequately controlled through diet and exercise alone. This pre-filled pen contains the initial treatment doses (0.25mg and 0.5mg), allowing patients to begin therapy gradually while helping their bodies adjust to semaglutide. It may be prescribed on its own or together with other antidiabetic medications and has demonstrated cardiovascular benefits in reducing the risk of major adverse cardiovascular events in adults with established heart disease.

The 0.25mg pen is intended for the initiation and dose-escalation phase of treatment. This dose is used during the first four weeks to improve tolerability and is not intended for long-term blood sugar control. After this period, patients are typically increased to 0.5mg once weekly, depending on their clinical response and their doctor's recommendation. While semaglutide may help reduce appetite and support weight loss as a secondary effect, this injection is primarily approved for managing type 2 diabetes. Any use solely for weight management in individuals without type 2 diabetes is considered off-label and should only be undertaken following a comprehensive medical assessment by a qualified healthcare professional.

The dosage prescribed will depend on your individual treatment plan, blood sugar control, and your doctor's clinical assessment. This pre-filled pen is designed to deliver either 0.25mg or 0.5mg of semaglutide per injection, allowing healthcare professionals to prescribe the appropriate dose based on your stage of treatment. Dose adjustments should only be made under medical supervision.

For some patients, treatment may begin with the 0.25mg dose before increasing to 0.5mg to improve glycaemic control, while others may continue at the dose recommended by their healthcare provider. If additional blood sugar control is required after treatment with this pen, your doctor may consider switching you to the Ozempic 1mg Pre-filled Pen.

Never change your prescribed dose without consulting your healthcare provider. If you miss a scheduled injection, administer it within 5 days. If more than 5 days have passed, skip the missed dose and continue with your regular weekly schedule. Do not inject an extra dose to make up for the missed one.

Common side effects during the early stages of treatment may include:

• Nausea
• Vomiting
• Diarrhoea
• Constipation
• Reduced appetite
• Mild stomach discomfort or abdominal pain
• Bloating or indigestion
• Fatigue

These side effects are generally more noticeable when starting Ozempic or increasing the dose from 0.25mg to 0.5mg and often improve as your body adapts to semaglutide. If symptoms persist, become severe, or you experience signs of pancreatitis, allergic reactions, or significant dehydration, seek immediate medical attention and contact your healthcare provider.

The shelf life of this pen is generally 2 years from the date of manufacturing, as indicated on the packaging. Always check the expiry date before use.

• Before first use: Store this Ozempic pen in a refrigerator between 2°C and 8°C.
• After first use: This injection may be stored below 30°C or kept refrigerated. Discard the pen 56 days after first use, even if it still contains medication.
• Do not freeze semaglutide. If the pen has been frozen, do not use it and dispose of it safely.
• Keep the medication away from direct sunlight, heat, and moisture.
• Store Ozempic in its original packaging to protect it from light.
• Keep this medicine out of the reach and sight of children.
• When travelling, transport the pen in an insulated cooler pack, but avoid allowing the medication to freeze.

Do not use Ozempic if you:

• Are allergic to semaglutide or any of the ingredients contained in this injection.
• Have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2).
• Are pregnant, planning to become pregnant, or breastfeeding unless specifically advised by your healthcare professional.
• Have severe kidney or liver impairment without prior medical assessment and supervision.
• Have been prescribed a different maintenance dose, as this pen is specifically intended for the treatment initiation and dose-escalation phase (0.25mg and 0.5mg) under your doctor's guidance.

Not sure if this is the right fit for you? Learn whether Ozempic is safe to use before you start.

• Semaglutide may slow the absorption of certain oral medications due to delayed gastric emptying. Inform your doctor or pharmacist about all prescription medicines, over-the-counter products, and supplements you are taking.
• This injection may increase the risk of hypoglycaemia when used together with insulin or insulin secretagogues such as sulfonylureas. Your doctor may adjust the dose of these medications accordingly.
• Excessive alcohol consumption may affect blood glucose control and increase the risk of hypoglycaemia. It is advisable to limit alcohol intake while using this pen.
• There are no specific food restrictions when using Ozempic. However, following a balanced diet and healthy lifestyle can help maximise treatment effectiveness and support long-term blood sugar management.

• Use this pen once weekly on the same day each week to help maintain a consistent treatment schedule.
• Store Ozempic properly in a refrigerator before first use and avoid freezing the medication.
• Rotate your injection site every week to help reduce the risk of skin irritation or discomfort.
• Monitor your blood sugar regularly as recommended by your healthcare provider, especially during the 0.25mg and 0.5mg dose escalation phase.
• Dispose of used needles and this injection pen safely in an approved sharps container or according to your pharmacist's instructions.
• Never share your semaglutide pen with anyone, even after changing the needle, to prevent the risk of infection.

This injection is administered under the skin (subcutaneously), usually into the thigh, upper arm, or abdomen, once a week on the same day each week. The starting dose is typically 0.25mg once weekly for the first 4 weeks to help your body adjust to the medication, after which your doctor will usually increase the dose to 0.5mg once weekly if appropriate. It can be taken at any time of the day, with or without food, but choosing a consistent day each week helps maintain an effective treatment routine.

This pre-filled pen is designed for simple self-administration and should always be used exactly as prescribed by your doctor or pharmacist. Rotate the injection site with each dose to reduce the risk of skin irritation. Avoid excessive alcohol consumption while using semaglutide, as it may interfere with blood glucose control and increase the risk of certain side effects. Quitting smoking is also encouraged to support better diabetes management and overall cardiovascular health. Never change your dose or injection schedule without consulting your healthcare professional.

Curious about the full picture before you commit? Our doctors also cover how to get started with Ozempic the right way, including what a first consultation actually involves.

Current Supply Status (As of 2026): While global supply chain constraints for GLP-1 receptor agonists (semaglutide) have historically affected retail pharmacies and hospital networks across Singapore, local availability continues to fluctuate based on international manufacturing allocations. Demand remains high as more patients begin treatment with the initial 0.25mg dose before progressing to the 0.5mg dose under medical supervision.

How DoctorOnCall Guarantees Authentic & Reliable Stock:
To help patients start and continue their semaglutide treatment without interruption, DoctorOnCall works through licensed, Ministry of Health-registered pharmacy networks across the border to source genuine, factory-sealed Ozempic pre-filled pens containing the 0.25mg and 0.5mg dosing schedule.

• Direct Sourcing from Authorized Distributors: Every Ozempic pen is sourced exclusively through licensed pharmaceutical supply channels, ensuring 100% authentic Novo Nordisk products complete with original batch numbers and traceable expiry dates.
• Temperature-Controlled Cold-Chain Logistics: To maintain the stability and effectiveness of this injection, DoctorOnCall utilizes specialized, temperature-monitored cold-chain shipping (2°C to 8°C) from our pharmacy directly to your doorstep in Singapore.
• Strict Regulatory & Prescription Verification: In accordance with Health Sciences Authority (HSA) guidelines for personal importation, DoctorOnCall's licensed medical team verifies every prescription before dispensing this prescription-only medicine, ensuring full regulatory compliance and patient safety.

Is it legal to buy or import Ozempic from Malaysia to Singapore?
Yes, this medication may be legally imported for personal use, provided it fully complies with the Health Sciences Authority (HSA) Singapore regulations governing the personal importation of health products. For Singaporean patients beginning or continuing treatment with Ozempic, purchasing this GLP-1 receptor agonist through a licensed Malaysian pharmacy must strictly follow HSA import requirements:

• Valid Prescription Mandatory: Under HSA regulations, prescription-only medicines (POM) such as semaglutide can only be imported when accompanied by a valid prescription issued by a registered doctor.
• 3-Month Personal Supply Limit: HSA guidelines limit personal importation to a maximum of three months' supply per shipment. Importing quantities beyond this limit without the necessary permits is prohibited under Singapore law.
• Strict Cold-Chain Logistics: Because this pre-filled pen contains temperature-sensitive biological proteins, it must be stored and transported continuously between 2°C and 8°C. Purchasing from unverified online sources increases the risk of counterfeit or improperly stored products. We use specialized medical cold-chain couriers to ensure safe, compliant transportation from Malaysia to Singapore.

Ozempic Pen vs. Rybelsus Tablet vs. Wegovy: Which is Right for You?

Although Ozempic, Rybelsus, and Wegovy all contain semaglutide, they are prescribed for different treatment stages and healthcare goals.

• Ozempic Pre-filled Pen: Administered once weekly during the treatment initiation and dose-escalation phase. This pen helps patients gradually adjust to semaglutide therapy before progressing to higher maintenance doses when clinically appropriate.
• Rybelsus (Oral Tablet): Taken once daily on an empty stomach. Suitable for adults with type 2 diabetes who prefer an oral treatment instead of weekly injections.
• Wegovy (Injectable Pen): Also contains semaglutide but is specifically developed and approved for chronic weight management in adults with obesity or overweight accompanied by weight-related medical conditions.

Not sure whether this pen, an oral semaglutide tablet, or a higher-dose injectable is the most suitable option? Speak with our licensed doctors or pharmacists to review your medical history and receive a personalised treatment recommendation.

1. How much does an Ozempic 0.25mg/0.5mg pen cost in Singapore?
Public market data indicates that the typical cost for this starter pen ranges from SGD 400 to SGD 600 per month, depending on your prescribed dose and healthcare provider. Please contact us for the latest pricing based on your medical documents.

2. What are the 0.25mg and 0.5mg doses used for?
These lower doses are commonly used during the initial phase of treatment. The 0.25mg dose is typically prescribed for the first few weeks to help the body adjust to semaglutide, while the 0.5mg dose is often used as the next step based on your doctor’s recommendation.

3. How is the medication shipped to ensure its safety?
As a temperature-sensitive injection, all orders are dispatched using specialized cold-chain delivery logistics. This ensures the pen remains properly stored between 2°C and 8°C from our licensed pharmacy dispatch center directly to your doorstep in Singapore. For complete delivery coverage, cold-chain handling, and shipping details, please visit our Shipping Information page.

4. Is this pen delivered to Singapore?
Yes, we arrange secure and trackable delivery to Singapore through licensed pharmacy networks and specialized medical couriers. Delivery generally takes 5–7 business days, depending on location and customs clearance.

5. Is this product authentic?
Absolutely. Every Ozempic pen is sourced through authorized pharmaceutical distributors and supplied in original manufacturer packaging with traceable batch numbers and expiry dates.

6. Is semaglutide doctor-approved?
Yes. Semaglutide is approved by major health authorities, including Singapore’s Health Sciences Authority (HSA), for the treatment of adults with type 2 diabetes.

7. Do I need a prescription?
Yes. Ozempic is a prescription-only medicine, and a valid prescription issued by a registered doctor is required before purchase.

8. How is this injection administered?
This medication is given as a subcutaneous injection once weekly. It may be injected into the abdomen, thigh, or upper arm, preferably on the same day each week.

9. What if I miss a dose?
If you miss your scheduled injection, administer it within 5 days. If more than 5 days have passed, skip the missed dose and continue with your next planned dose. Do not inject an extra dose to make up for a missed one.

10. Can I use it with other diabetes medicines?
Yes, but always inform your doctor about all medications you are taking. Particular caution is needed when using insulin or sulfonylureas, as combining treatments may increase the risk of low blood sugar.

11. How should I store the pen?
Before first use, keep this semaglutide pen refrigerated between 2°C and 8°C. After opening, it may be stored below 30°C or refrigerated and should be discarded after 56 days. Do not freeze, and protect it from direct sunlight.

12. Is it safe for long-term use?
Yes, when used under appropriate medical supervision. Many patients continue treatment long term for type 2 diabetes management, depending on their clinical response and doctor’s recommendation.

13. What should I do if I experience severe side effects?
Seek immediate medical attention if you develop symptoms such as severe abdominal pain, persistent vomiting, allergic reactions, or signs of pancreatitis.

14. Can I use this medication during pregnancy or breastfeeding?
No. This GLP-1 receptor agonist is generally not recommended during pregnancy or breastfeeding. Consult your doctor to discuss suitable alternatives.

15. Do you offer promotions or vouchers?
Yes, promotions may be available from time to time. Please visit our website or subscribe to our newsletter to stay updated on the latest offers.

16. Is it legal to import Ozempic into Singapore for personal use?
Yes, personal importation may be permitted when it complies with Health Sciences Authority (HSA) regulations, including possession of a valid prescription and adherence to personal supply limits.

17. What are the delivery fees to Singapore?
Shipping fees vary depending on the destination, delivery method, and cold-chain requirements. Please refer to our shipping information page or contact customer support for the latest rates.

Ozempic (Semaglutide) is available in different strengths to support blood sugar control in adults with type 2 diabetes. It helps improve glycaemic control and may aid in weight management when combined with diet and exercise. Your doctor will determine the appropriate dose based on your treatment goals and response.

• Ozempic (Semaglutide) 1.34mg/ml (1mg/dose) Pre-filled Pen 3ml x1 (pen) – The higher strength pen used for maintenance dosing once the initial titration period is complete.
• Ozempic (Semaglutide) 1.34mg/ml (0.25mg, 0.5mg/dose) Pre-filled Pen 1.5ml x1 (pen) – Lower dose options suitable for treatment initiation and gradual dose escalation to minimize side effects.

You can buy Ozempic online in Singapore and Malaysia through licensed online pharmacies offering authentic, temperature-controlled medication with secure delivery.

For safe and effective use, consult a registered doctor online to determine the right starting dose and dosing schedule for your needs.